VDR is a gene which codes for a protein that acts as a receptor for vitamin D that regulates bone formation and calcium absorption. A variant of the gene, rs2228570 (FokI polymorphism) is associated with a decrease in bone mineral density in white prepubescent girls.

The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is controlled by the reciprocal and temporal pattern of off- and on- occupancy of the VDRE by two components, and is influenced through chromosomal sites and binding preferences for specific hormones. Microarray studies of human cells reveal that more than 100 genes contain a gescheftmarketing.de/2021/09/01/microsoft-teams-vs-zoom-which-one-is-better/ VDRE. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.

A virtual dataroom (VDR) could be a repository of data and documents that are relevant to business, legal transactions or other proceedings. Viewing, downloading or printing is restricted. It utilizes central servers and an extranet connection, which is an Internet connection with restricted access, to offer controlled log-on for set intervals during which users can view the data and documents.

VDRs are used most often by investment banks and businesses involved in mergers or acquisitions. They require to communicate information in a clear manner with potential investors and buyers. The due diligence process can also require a large amount of data. Life science companies also use VDRs to keep everything from clinical trials results to HIPAA documentation.